Advancing health through cutting-edge therapies and R&D.
Innovative Solutions in Medical Research
Advancing health through cutting-edge therapies and R&D.
Advancing Medical Science with Biofilm Therapeutics
Cutting-Edge Research Facilities
Our research facilities are equipped with the latest technology and equipment, allowing us to conduct groundbreaking research and make new discoveries.
Dedicated Research Team
Our team of experienced researchers and scientists are passionate about advancing medical science and improving patient outcomes through innovative research.
Patient-Centered Research
Our research is focused on improving patient outcomes and quality of life. We prioritize the needs and perspectives of patients in all aspects of our work.
Innovative Research Areas
At Biofilm Therapeutics, we are at the forefront of developing innovative therapies for treating biofilm-related infections. Our dedicated team conducts extensive research to understand the complexities of biofilms and their impact on patient health. We aim to create solutions that enhance treatment efficacy and improve patient outcomes.
Research project on bacterial biofilms
Bacterial biofilms are the root cause of intractable skin and eyelid diseases, in addition to numerous device and wound associated infections. Conditions including Blepharitis, Acne rosacea and Acne vulgaris all have a common pathogenesis due to chronic inflammation associated with biofilms. A major objective of this proposal is to develop and validate a unique ex vivo model for blepharitis and acne biofilm pathology using pig skin epidermal explants on which mature mono-species and dual-species bacterial biofilms of relevant pathological bacteria (Staphylococcus aureus, Pseudomonas aeruginosa, Streptococcus epidermidis, Cutibacterium acnes) will be grown. Key parameters that will be assessed include insuring that the stratified layers of normal epidermis are intact and provide an effective epidermal barrier for water vapor transmission and prevents planktonic bacteria penetrating into dermal tissue layers. Also, it will be essential that the skin microstructures, including hair follicles, oil glands and their duct structures remain intact after sterilization of the pig skin explants.
Previous research performed by laboratories in the Institute of Wound Research at the University of Florida showed that a base formulations generated by Biofilm Therapeutics that consist of the patented combinations of monolaurin (ML) sucrose laurate (SL) and L-arginine ethyl ester (LAE) were able to rapidly (within 24 hours of exposure) and effectively (>6-log reduction) eliminate mature biofilms formed by common wound pathogenic bacteria (Staphylococcus aureus, Pseudomonas aeruginosa, Streptococcus epidermidis) and yeast (Candida albicans) that were grown in polystyrene 96-well plates. Furthermore, selected formulations were further tested using the ex vivo pig skin dermal explant mature biofilm model developed at the University of Florida that reproduces key conditions that exist in the wound beds of chronic skin wounds such as diabetic foot ulcers or venous leg ulcers. Results obtained from tests performed with the pig skin dermal explant biofilm model showed that optimization of Biofilm Therapeutics formulations were able to achieve clinically relevant reductions mature biofilm communities in 24 hours of exposure. These results support the hypothesis that basic ingredients in the Biofilm Therapeutics antibiofilm formulation can be combined in optimized formulations to effectively kill and remove mature bacterial biofilms that are the cause of the chronic infections in pathological conditions including blepharitis (with associated dry eye syndrome) and skin acne.
Revolutionizing Medical Research
Cutting-Edge Technology
Our state-of-the-art technology allows us to conduct research more efficiently and accurately than ever before. This means faster results and better outcomes for patients.
Expert Team
Our team of experienced researchers and medical professionals are dedicated to advancing the field of medicine. We bring a diverse range of skills and expertise to every project.
Collaborative Approach
We believe that the best results come from working together. That's why we collaborate with other researchers to achieve our goals.
Patient-Centered Focus
At Biofilm Therapeutics, we put patients at the center of everything we do. Our research is designed to improve the lives of patients and provide better treatment options for a wide range of medical conditions.
Innovative Solutions
We're always looking for new and innovative ways to approach medical research. Our team is constantly exploring new technologies, techniques, and approaches to achieve our goals.
Leaders in the Industry
With years of experience of out team and a proven track record of success in adjacent microbiological areas , we're proud to be recognized as leaders in the medical research and development industry.